The Epac2 Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to RAPGEF4. This antibody recognizes Human, Mouse, and Rat antigen. The Epac2 Antibody has been validated for the following applications: EIA, Immunoassay, and ELISA.
Description
Function: Guanine nucleotide exchange factor (GEF) for RAP1A, RAP1B and RAP2A small GTPases that is activated by binding cAMP. Seems not to activate RAB3A. Involved in cAMP-dependent, PKA-independent exocytosis through interaction with RIMS2 (By similarity).
Subcellular Location: Cytoplasm. Membrane>Peripheral membrane protein.
Tissue Specificity: Predominantly expressed in brain and adrenal gland. Isoform 2 is expressed in liver. Isoform 1 is expressed in liver at very low levels.
Subunit Structure: Interacts with RIMS1 and RIMS2. Probably part of a complex with RIMS2 and GTP-activated RAB3A (By similarity).
Similarity: The N-terminal nucleotide phosphate binding region cAMP 1 has a much lower affinity for cAMP as compared to cAMP 2.The DEP domain is involved in membrane localization independent from regulation by cAMP